Jose Calderon had 16 points and nine assists, newcomer Jerryd Bayless added 13 points, Leandro Barbosa had 11 and the Raptors matched a season high with nine 3-pointers.
Andre Iguodala scored 17 points, Jrue Holiday had 16 and Thaddeus Young 14 for Philadelphia. The 76ers have lost seven of eight.
Toronto started its winning streak with a 94-86 victory at Philadelphia last Wednesday.
The 76ers trailed 87-71 after three quarters, then cut the gap to 10 at 98-88 on Marreese Speights' consecutive dunks. But Philadelphia didn't score again after Iguodala made two free throws with 3:36 remaining, allowing Toronto to close out a comfortable win.
The 76ers were without forward Elton Brand, suspended without pay for one game after committing a flagrant foul on Wizards center JaVale McGee on Tuesday night in a 116-114 loss in Washington. Young started in place of Brand.
Bayless and forward Peja Stojakovic, acquired Saturday in a trade with New Orleans that sent David Andersen, Marcus Banks and Jarrett Jack to the Hornets, made their Toronto debuts. Bayless played 15 minutes and Stojakovic scored seven points in 6 minutes.
Evans had 10 rebounds and Bargnani scored eight points to help the Raptors open a 33-18 lead after a quarter, with Bayless adding a 3-pointer at the buzzer.
Bargnani scored seven points in the second, and Stojakovic came off the bench to add seven more, giving Toronto a 62-43 lead at the half.
Evans led Toronto with eight points in the third, helping the Raptors carry a 16-point advantage into the final quarter.
The 76ers are 1-8 on the road. Only Washington (0-6) and the Los Angeles Clippers (0-7) have worse records away from home.
NOTES: Evans had 15 rebounds in the first half, a Raptors record. His previous career high was 21, set Feb. 5, 2005, against Charlotte. ... Two of Philadelphia's starters, center Spencer Hawes and rookie swingman Evan Turner, failed to score in the opening half. ... The Raptors will visit Boston on Friday night, while the 76ers are at Miami.