The crash happened just after 1:00 a.m. in Egg Harbor Township.
The driver of an SUV travelling northbound lost control near mile marker 35.
The vehicle went off the parkway and rolled several times, trapping its occupants inside.
Fire crews were able to free the victims from the vehicle.
A male victim was taken to Atlanticare Regional Medical Center, where he is listed in critical condition.
No word on the exact cause of the crash.