Guilford County Sheriff BJ Barnes says the victims were found in three different locations near Greensboro around 9:30 a.m. Sunday.
Barnes says one person was found wounded in a parking lot. The sheriff says officers then found the gunwoman on a nearby road and that she had shot himself. A second wounded person was found in the back seat.
Deputies then went to a nearby home, where one person was found dead and three more injured.
Barnes says four victims are younger than 18. He says they all knew each other and some are related.
The sheriff says three of the injured are on life support. Deputies say no more information will be released until Monday morning.