Ramon Rodriguez, 44, was last seen at his home in the 4300 block of Penn Street at approximately 7:26 p.m. on Saturday.
Rodriguez suffers from Schizophrenia and police are calling him "endangered."
He is described as 5'2" in height weighing 150 pounds. He has hazel eyes and short black hair.
Rodriguez was last seen wearing blue pants, a plaid fleece shirt, white/blue sneakers, silver framed glasses with blue tinted lenses and a blue baseball cap.
Anyone with information on the whereabouts of Ramon Rodriguez is asked to contact Northeast Detective Division at 215-686-3153 or call 911.