The robbery took place shortly before 7:00 p.m. at Silver Perfumes located along the 3200 block of North Front Street.
Police say an 18-year-old employee was pistol-whipped and duct taped during the holdup.
$100 was taken, along with cell phones, body oils, and jewelry.
All four suspects, described as three males and a female, fled the scene on foot and were last seen running northbound on Front Street towards Westmoreland.
Police say one of the men brandished a gun.