The Phillies were 0-42 when trailing after eight innings before coming back against Rodriguez, who replaced John Axford as the closer last week.
With one out, Jimmy Rollins walked, Juan Pierre singled and Chase Utley walked to load the bases. Ryan Howard ripped an 0-2 pitch up the middle to drive in a pair and cut it to 6-5. Carlos Ruiz followed with a line-drive hit to left-center to tie it at 6. Hunter Pence walked to load the bases again.
Eric Kratz entered to run for Howard. Wigginton followed with a liner to left and Kratz scored easily ahead of Ryan Braun's off-target throw.
Rodriguez (2-5) has blown five saves in eight tries.
