The ticket, which was sold at Centre Square News, located at 1500 Market Street, correctly matched all five white balls, 32-34-45-52-58, but not the Powerball, 20, for a $1 million second-tier prize.
Centre Square News will be awarded a $5,000 bonus for selling the winning ticket.
Lottery officials say the winner has yet to come forward, and in Pennsylvania, Powerball winners have one year to do so.