Matthew Petke, 39 and Brenda Petke, 45, were killed in the crash on Sunday night.
The crash happened around 7:00 p.m. on Route 41 in front of the Taqueria Moroleon Mexican Restaurant in Kennett Township, near the Delaware-Pennsylvania state line.
Officers say the car had just pulled out of the parking lot on Gap Newport Pike when it was hit by the passing tractor trailer.
The tractor trailer then went off the roadway, puncturing its gas tanks.
The tractor trailer driver, 35-year-old John Deapen, was uninjured.