The crash occurred shortly after 8:30 p.m. along the 9500 block of Bustleton Avenue.
Police say a passenger van and a car collided, with the car coming to rest off the roadway where it struck a utility pole.
The 23-year-old male driver of the car and his 23-year-old passenger were injured, along with the driver of the van.
All three were rushed to Aria Hospital Torresdale Division for care.
The car driver and passenger suffered non-life-threatening injuries.
There is no further information at this time on the injuries sustained by the driver of the van.
Police are conducting an investigation into what led to the crash..