Vick, the four-time Pro Bowl quarterback, and McCoy, the All-Pro running back, have been ruled out because of concussions. Vick is missing his third straight game and McCoy his second in a row. Neither has even been cleared to begin practicing since getting hurt.
Vick remains in stage four of five in his recovery and McCoy is in stage two, according to head athletic trainer Rich Burkholder.
The Eagles (3-8) have a seven-game losing streak entering their divisional rematch against the Cowboys (5-6) in Dallas.
Two-time Pro Bowl wide receiver DeSean Jackson (ribs) is out for the rest of the season. Starting center Dallas Reynolds (ankle) and rookie defensive tackle Fletcher Cox (tailbone) are questionable