It happened around 6:30 Saturday night in the northbound lanes of I-95 near Neshaminy Creek. The southbound lanes were briefly shut down but have since reopened.
Initial reports indicate that several cars were involved in the accident.
Two people were killed and four others were hospitalized.
Two victims were taken to Aria-Torresdale Hospital, one was taken to St. Mary's Medical Center and another was taken to Temple University Hospital. No word on their conditions.
Four ambulances and a helicopter were sent to the scene.
Stay with Action News and 6abc.com as this story develops.