The train derailed from a bridge near N. Commerce St. into the Mantua Creek near the Delaware River around 7:00 a.m. Friday.
Four train cars fell off the bridge and went into the water below.
Seven people have gone to the hospital with respiratory problems. Another six people are being decontaminated at the scene and are being prepped for transport to the hospital.
According to the EPA's website, short-term exposure to vinyl chloride can cause dizziness, drowsiness, and headaches.
Long-term vinyl chloride exposure has been shown to increase the risk of a rare form of liver cancer, the EPA says, and has classified vinyl chloride as a Group A human carcinogen.
Everyone in nearby Paulsboro High School is being kept in the school - no one is permitted to leave and no one is allowed to enter the school at this time.
The same shelter-in-place policy has been put in place for the entire area, in an effort to keep nearby residents indoors.
Stay with Action News and 6abc.com as more information becomes available.