It happened around 3:00 Sunday morning near the intersection of North 27th and Clearfield streets.
Authorities received reports of multiple shots fired and a vehicle that had crashed.
Police later learned that a woman in her 40s was driving her 2000 GMC Yukon down North 27th Street when someone opened fire on her vehicle.
The woman kept driving a block down before she lost control and crashed into Whittier Elementary School.
Arriving officers found the woman inside her SUV with multiple gunshot wounds.
The victim was taken to Temple University Hospital where she was pronounced dead. No word on her identity.
Police believe the woman was targeted in the shooting but have not released any additional information.