It happened at 3:30 p.m. Wednesday at the intersection of Tyler and Anderson Streets.
At least one person was taken to an area hospital. There is no word on that person's age or condition.
Trenton has faced a rash of violent shootings over the last several days.
Eight people have been shot and one killed in Trenton since Sunday.
Trenton Mayor Tony Mack released the following statement after Wednesday afternoon's shooting:
I am absolutely FED UP with the wanton violence that plagues our city. Our administration has made concerted efforts to reduce crime, everything from hiring additional police officers to transferring officers with desk jobs to our patrol bureau. The escalating violence requires us to do more and we will continue to meet that challenge. We continue to encourage residents to be engaged and attend C.P.A.C. and other community stakeholder meetings. The Trenton Police Department can no longer be expected to carry the burden of crime reduction on its own. Parents and guardians need to step up and take control of their homes and children. For those who need help, speak up and speak out. Our administration will continue to do its part by reaching out to state officials to secure additional public safety dollars.