It happened around 2:45 Saturday morning on the 7300 block of Ogontz Avenue in West Oak Lane.
Authorities say the driver of a Pontiac Firebird lost control, crossed into the oncoming lane and struck a parked Dodge Durango.
The impact of the crash sent the Durango into a parked minivan, which then was pushed onto the roof of a Ford Escort.
Police say one of the men in the Firebird was able to climb out but the driver had to be freed by firefighters.
Both men were taken to Albert Einstein Hospital for non-life threatening injuries.
Police are still investigating.