Police say the driver of a black Honda Civic crossed over the center line in the 4000 block of Aramingo Avenue and struck a Buick head-on just after 2:30 a.m.
Seconds later, the driver of a Ford Focus struck both vehicles.
Police say the driver of the Honda, 25-year-old Angelo Mills, was killed on impact
Three other people were taken by ambulance to Hahnemann Hospital. One person was listed in critical condition, another in stable condition and the third suffered a broken ankle.
The accident remains under investigation.