It happened before 9:00 p.m. Friday on Route 72 near mile marker 2 in Woodland Township.
Police say two vehicles collided, sending both off the highway.
Two medical helicopters were dispatched to the scene and transported at least two people to Cooper University Hospital.
The injuries were said to be very serious.
Traffic along Route 72 was down to one lane as police investigated and crews prepared to clear the wreckage.
