The crash happened around 2:30 a.m. Friday at the Villanova/St. Davids exit.
Police say a driver lost control of a car. The vehicle rolled over and landed on its roof.
One person was ejected from the vehicle and pronounced dead at the scene.
There was no immediate word as to how many people were in the car.
The highway was closed for the investigation but reopened shortly after 7:30 a.m.