The blaze broke out around 6:50 a.m. near Cape May and 10th Avenues in the Dorothy section of Weymouth Township.
New Jersey State Police say once the flames were extinguished, firefighters found a man and a woman, both in their 50s.
The woman was pronounced dead at the scene.
Medics took the man to an area hospital. He did not survive.
The camper was parked in some woods behind a home when it caught fire.
Investigators are working to determine the cause.