The incident occurred around 12:30 a.m. on the 600 block of Solly Avenue.
Authorities say two males and two females in their 20's and 30's were inside watching television when two men barged into the home.
According to police, the two suspects were armed, wearing masks, hooodies and gloves and came in demanding money.
The men allegedly threatened the victims and three of the victims were duct taped and two were injured.
One male suffered a dislocated shoulder and a female suffered scrapes and bruises.
Both were taken to Jeanes Hospital for treatment.
The suspects fled the scene on foot from the back of the home. No word if anything was taken.
Police are investigating.