It happened Sunday morning at 1000 Colts Circle.
Firefighters arrived and heard someone yelling for help inside the apartment.
The victim, 86-year-old Barbara Vocolo, was found lying in her bed.
She was taken to Capital Health Systems and later flown to Temple University with burns to approximately 90 percent of her body.
Authorities say the fire originated at the foot of Vocolo's bed. Officials do not suspect foul play.
The cause of the fire remains under investigation.