The shooting happened shortly after 4:30 p.m. Thursday at the intersection of Honan and Leighman streets.
Police say someone opened fire on the occupant of a GMC SUV. That person traveled a short distance then crashed into a fence.
Paramedics responded to the scene and rushed the victim, described as a 21-year-old man from nearby Chester Township, to Crozer Chester Medical Center.
At this time no arrests have been made and police have yet to determine a motive.
This was the second shooting in the city on Thursday, which followed a very heated meeting about crime held the night before.