It happened Saturday night on the 3800 block of Governor Printz Boulevard after a 63-year-old man made a purchase at the liquor store.
Police say the man was shot multiple times as he got into his car around 10 p.m.
"As he returned to his car and sat in the driver seat, an unknown suspect approached the vehicle and fired multiple rounds at the victim before fleeing on foot," said Wilmington police.
The victim was rushed to an area hospital where he later died. He has not been identified.
No arrests have been made. Anyone with any information is asked to contact Detective Mark Csapo by calling 302-741-2729. Information may also be provided by calling Delaware Crime Stoppers at 1-800-TIP-3333.