It happened just before 2:30 p.m. when police say an unknown suspect opened fire onto a group of people standing outside near Broad Street and Chew Avenue in the city's Fern Rock neighborhood.
Chopper 6 was overhead as police cordoned off the crime scene where at least 24 shots were fired.
Police confirm a 26-year-old man died in the shooting. He has not been identified.
The five other victims, who police say are between 19 to 28 years old, were rushed to area hospitals where they were placed in stable condition.
According to Deputy Commissioner Joel Dales, the shooter was believed to be in the backseat of a silver Chrysler 300 with dark-tinted windows when the gunfire rang out.
"The vehicle was traveling eastbound on the 1300 block of West Chew Avenue from Broad (Street) when the shooting occurred," said Dales. "It's a busy area. Thank God that children were not out when the shooting occurred."
The shooting happened one block north of SEPTA's Olney Transportation Center, one of the busiest hubs in the city. Eight people were shot at the transportation center back in February.
"This is outrageous!" said Councilmember Cindy Bass of the gun violence. "This should not be happening. And where is our mayor? We need our mayor to engage, act like you care, come on out and see what's happening."
In response to Bass' statements, Mayor Jim Kenney's office said at the time of the shooting he was on a Zoom meeting working to get more funding from the Biden administration to address the root causes of gun violence.
"The mayor has demonstrated a commitment to gun violence, and there is no greater priority for his administration," said the mayor's office in a statement.
No arrests have been made. Police are searching for multiple suspects at this time.
Anyone with any information is asked to call police at 215-686-TIPS.