Police said the car was involved in a road rage confrontation where the driver shot and killed a man in broad daylight in front of his wife and kids at the intersection of 52nd and Warren streets on Friday morning.
The victim has been identified as 25-year-old Shaquil Mack from the 1200 block of Van Kirk Street of Northeast Philadelphia.
Police said it started when the shooter's car almost collided with a GMC Terrain.
According to police a heated exchange then took place, and that is when the man in the passenger seat of the Terrain got out of the car.
"He was sitting in the car with the mother of his children two of his children, I believe the nephew of the child's mother, so the kids were witnesses," said Philadelphia Police Captian Sekou Kinebrew.
Officers are looking for a mid-to-late 2000s Chrysler 300 with black tinted windows.
According to investigators, the car has some distinctive features, such as a dent on the rear passenger-side wheel well and the molding is missing from the rear passenger door.
The driver of the Chrysler is described as an African-American man in his late twenties or early thirties with dreadlocks or braided hair. Police believe there was a second person in the Chrysler as well.
If you should spot the car, police are asking you not to attempt to approach the vehicle, but instead call 911 immediately.