"Elton John is one of the most inspirational musicians and philanthropists in this industry for me," Blige said in a statement Tuesday. "I respect him with all my heart, and it is truly a pleasure to be performing with him on such an important night as we look to raise awareness and vital funds for the fight against HIV/AIDS."
John's annual Oscar party has raised more than $15 million over the past 15 years. Blige's AIDS-awareness efforts date back to 2000, when she worked with MAC Cosmetics on its Viva Glam fundraising campaign.
The "queen of hip-hop soul" has also worked with John before.
He played piano on her single "Deep Inside." No word yet on what song the two will perform at the Oscar party.