Oz has been featured on Winfrey's show for five years and 55 episodes. He would often offer diet tips or discuss life-threatening diseases.
Tuesday's show ends with Oz and Winfrey raising a champagne toast.
According to Oz's biography on Oprah.com, the best-selling author and heart surgeon is a surgery professor at Columbia University and directs the Cardiovascular Institute and Complementary Medicine Program at New York-Presbyterian Hospital.
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