Ohio fire marshal's spokesman Shane Cartmill said firefighters were called to the trailer at 6:30 a.m. in Greenwich, about 75 miles southwest of Cleveland.
John and Lisa Schunatz and their children, 6-year-old Jeffery and 4-year-old Valerie, were killed in the fire.
Daniel Schunatz, 5, was taken to a hospital in Akron, but his condition was not known.
Raymond Reed, manager of the mobile home park, said the Schunatz family had lived there for about five years.
Reed was somber as he watched firefighters clear debris from what was left of the mobile home.
"I'm at a loss for words," he said. "It's just a horrific thing."
The cause of the blaze is not known.
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Information from: News Journal, http://www.mansfieldnewsjournal.com
