Boris Diaw contributed 13 points for the Bobcats (32-31), who entered the game in seventh place in the Eastern Conference playoff race. The Bobcats, who have never advanced to the postseason in their six seasons, improved to just 9-23 on the road.
Tyson Chandler had 12, while D.J. Augustin and Tyrus Thomas had 10 apiece for Charlotte.
Rodney Carney led the Sixers with 14 points. Andre Iguodala and Jrue Holiday each added 13 for Philadelphia, which fell to 23-41 and 10-20 at the Wachovia Center.