The accident happened just before 6:00 a.m. Monday on the northbound lanes of Rt. 295 near Exit 19 in Paulsboro, New Jersey.
Police say the driver lost control, left the road, rolled over and landed near a utility pole.
All four victims were transported to the hospital with various injuries. Three were taken to Cooper University Hospital with serious injuries. One person was taken to Underwood Hospital in critical condition.