The shooting occurred at approximately 12:05 a.m. Monday on the 1400 block of N. Dover Street.
Police say a 16-year-old boy was shot multiple times through the body. He was transported to Temple Hospital in critical condition.
The female victim is 19 years old. She was transported to Hahnemann Hospital also in critical condition.
There have been no arrests in this shooting and no word on a suspect or motive.