The plans have been in the works since the Phillies' World Series Championship in 2008.
It is a tribute to the history of the oldest, continuous 'one name, one city franchise' in all of professional sports.
"When you think about the Phillies, it's not really just the team. They help define Philadelphia," Executive Director of the Philadelphia Mural Arts Program Jane Golden said.
The Phanatic even showed up to help unveil the new mural design.
It covers the Phillies from 1890 when Ed Delehanty hit four homeruns in one game to 1915 when Grover Cleveland Alexander. There's Tug McGraw from the Phils' 1980 World Series Championship, sluggers Mike Schmidt and Ryan Howard and Phils' closer Brad Lidge.
The mural wouldn't be complete without number #32 Steve Carlton and the late great Harry Kalas.
Award winning artist David McShane designed and will create the 8-story mural located on 24th and Walnut streets facing the Schuylkill River and Expressway.
He's also known for his Jackie Robinson mural in North Philadelphia and a tribute to the 1930's Negro League's team in Parkside.
"The motion of the athletic figure while in action is really captivating to me and I love trying to capture that in my paintings," McShane said.