The incident took place around 7:30 p.m at E and Ontario Streets in West Kensington.
Police say the suspect first pointed a gun at civilians in the area of the 3200 block of North E Street and that's what prompted them to respond.
Authorities say the man then fired at police as he was driving north along E Street.
Officers returned fire striking the man, who crashed his SUV at E and Ontario.
He was found dead laying outside the vehicle that came to rest against a corner store.
The man's identity has not been released.