The accident was reported just before 9:00 p.m. in the 2500 block of East Kings Highway in Coatesville.
Police say two vehicles collided, causing one of those vehicles to overturn.
The injured teens were taken to Paoli Memorial Hospital with serious injuries.
The ages and identities of the victims have not been released.
The accident caused some damage to power lines causing officials to shut down traffic while PECO makes the necessary repairs.
Police are investigating.