It happened at 8:00 a.m. Thursday in the 700 block of Stuyvesant Avenue near Hermitage Ave.
Fire officials tell Action News the impact of the crash sent one vehicle off the road.
It came to rest along the side of the Trenton Fire Department's Engine 8 firehouse.
There was no significant damage to the building.
Two people were taken to an area hospital. The extent of injuries was not immediately clear.