Penn State, with coach Joe Paterno coaching from the press box for the fourth straight game, solidified its position as a national championship contender and also erased the ugly memories of an 0-7 mark in Columbus since joining the Big Ten in 1993.
Defenses controlled most of the game before an Ohio Stadium-record crowd of 105,711.
Ohio State had the ball and a three-point lead when Terrelle Pryor fumbled, defensive back Mark Rubin using his left hand to knock the ball away as the freshman quarterback carried on a third-and-1 early in the fourth quarter. Penn State linebacker Navorro Bowman fell on the loose ball at the Buckeyes 38 after players scrambled to recover.
Immediately, the Nittany Lions were at a disadvantage as Clark remained on the sideline. He was meeting with team doctors. In stepped Devlin, who had seen action in seven games but had only been on the field for 45 plays.
He promptly led the way on a seven-play, 38-yard drive that took 4:13 and ended with his touchdown giving Penn State a 10-6 lead. The big play in the march came on third-and-2 at the Ohio State 6 when Royster skirted right end, tiptoeing along the sideline for a 4-yard gain and the first down.
Three plays later, Devlin scored on his second straight keeper and Kevin Kelly converted the point-after for a 10-6 lead with 6:25 left.
Penn State's defense then forced an Ohio State punt, and with Royster carrying most of the load, the Nittany Lions almost ran out the clock. Royster went for 3, 10 and 9 yards on his first three carries before Devlin sneaked for a first down at the Ohio State 24.
While the Buckeyes were using all their timeouts, the Nittany Lions continued to stick to the ground attack. Finally, they let the clock run down until Kelly converted a 35-yard field goal with 1:07 left to push the lead to 13-6.
Ohio State had one last chance to tie it. Taking over at their own 20, Pryor hit Ray Small for gains of 23 and 14 yards to the Penn State 43 with just over 30 seconds left. But Pryor's long pass to the goal line was intercepted by cornerback Lydell Sargeant with 27 seconds left.
Paterno couldn't celebrate with his players. At least not right away.
Penn State's coach for the past 43 years, the 81-year-old Paterno came up from the team locker room about 15 minutes before the opening kickoff, using a cane and with a Penn State athletic administrator following him in case he needed assistance.
Pryor, the nation's most heralded quarterback recruit last spring, completed 16-of-25 for 226 yards with the one interception. He ran for 6 yards on nine attempts. Tailback Chris "Beanie" Wells managed just 55 yards on 22 carries against Penn State's stout defense.
For the Nittany Lions, Clark completed 12-of-20 passes for 121 yards before leaving. Royster had 77 yards on 19 carries.
Kelly, who became the Big Ten's all-time kick scorer a week ago, came into the game 12-of-14 on field goals. He converted one of 31 yards in the first half.
But with the Nittany Lions trailing 6-3, he hooked one wide right on the second play of the fourth period that would have tied it. At the time, it looked like a costly miss.
The teams traded punts - and occasional big gainers - in the opening half while fighting to a 3-3 tie.
The two quarterbacks - Penn State's Clark from Youngstown, Ohio, and Ohio State's Pryor from Jeannette, Pa. - had almost identical first-half stats. Clark completed 8 of 14 passes for 91 yards and gained 16 yards on five rushes. Pryor hit on 9 of 14 passes for 131 yards and gained 5 yards on five carries.