The Wildcats rushed for six touchdowns, including two by Lawrence Doss. Doss rounded out the Wildcats' scoring on a 5-yard run with 9:55 remaining and a 14-yard run with 4:18 left.
Chris Whitney added 98 yards on 10 carries for Villanova (4-0) in the conference opener for both teams.
Whitney also was 7-for-11 with 84 yards and a passing and rushing touchdown as Villanova moved to 7-1 all-time against Northeastern (0-4).
Alex Dulski was 16-for-31 with 138 yards, a touchdown and three interceptions for the Huskies.