Jonathan Jackson will retake the role he started at age 11 and left a decade ago to pursue other acting jobs and a music career.
As a preteen and teenage Lucky Spencer, Jackson won three daytime Emmy awards.
When Jackson left the show in May 1999, actors Jacob Young and then Greg Vaughan assumed his spot.
Jackson's return as Lucky Spencer is a big deal for many "General Hospital" fans. Message boards and Web sites devoted to the show have viewers curious to see what will happen next. And some fans say they'll watch again because of Jackson's return.