In her first interview since her husband's death, Vicki Kennedy will appear on Winfrey's television talk show Wednesday, along with her stepson, Ted Kennedy Jr., and her two children from a previous marriage, Caroline and Curran.
Sen. Kennedy died in August at age 77, just weeks before the release of his memoir, "True Compass."
Winfrey, who announced last Friday she would end her program in 2011, recently had the first interview with Sarah Palin as the former Alaska governor promoted her memoir, "Going Rogue."
