Investigators say that at about 2:45 in the morning, the officers began chasing the Dodge with three people in it, because it was speeding on I-95 in Philadelphia.
Officers say the van got off the highway then raced through the Frankford section of the city.
At one point it went out of control and hit several parked vehicles.
Then it came to a dead end at a cemetery in the 5400 block of Walker Street.
As officers got out of their patrol cars and started approaching the van, the van turned and started speeding toward them.
At least one officer opened fire, hitting the 16-year-old driver in the shoulder.
The driver has been taken to Hahnemann Hospital, where there's no word on his condition.
Police have taken into custody the two other people in the vehicle.
None of the officers were injured.
Officials believe this is the first case of a State Police officer firing his weapon in the city since the officers began patrolling state highways in Philadelphia.