Officers were called to a report of shots fired in the area of Vandever Avenue and Locust Street in Wilmington shortly after midnight Sunday.
While en route, two victims showed up at Wilmington Hospital in a personal vehicle.
One victim, a 28-year-old man, was shot numerous times and was pronounced dead.
The other victim, a 16-year-old boy, was also shot numerous times but was listed in stable condition.
Police are investigating and there is no word yet on a suspect or motive.
Anyone with information is asked to call Detective Steve Morrissey at 302-576-3645 or Delaware Crime Stoppers at 1-800-TIP-3333.