The accident happened at approximately 7:20 a.m. on the ramp from I-295 to Route 9.
The truck was carrying a load of fruit when it turned over. The guard rail sliced part of the cab portion in half.
The driver, said to be from Ontario, Canada, was taken to Christiana Hospita, having suffered only non-life threatening injuries.
The ramp is expected to stay closed until at least noon today, however traffic delays are not expected.
Police say charges are pending.