NBC said it had hired the 31-year-old Clinton to work on projects for "NBC Nightly News" and Brian Williams' newsmagazine, "Rock Center." She will report stories for the feel-good "Making a Difference" series.
The only child of former President Bill Clinton and Secretary of State Hillary Rodham Clinton is pursuing a doctorate at Oxford and working for the Clinton Foundation and Clinton Global Initiative.
Former President George W. Bush's daughter Jenna Bush Hager does stories for the "Today" show.
NBC said Chelsea Clinton wasn't available for an interview, but issued a statement: "People who imagine and implement solutions to challenges in their own lives, in their communities, in our country and in our world have always inspired me."
Recent "Making a Difference" stories highlighted a 7-year-old boy raising money for a friend with cancer by racing go-karts, a marathon runner raising money for his mother who suffers from Parkinson's disease and rock star Bon Jovi opening a restaurant where people who cannot pay for meals can do volunteer work to earn food.
NBC News President Steve Capus said that "given her vast experiences, it's as though Chelsea has been preparing for this opportunity her entire life."
NBC is owned by NBC Universal.