Police say the car left the highway, landing onto Grant Avenue and James Street just after 6:00 Tuesday morning.
Police and rescue crews responded to the scene to find the vehicle on its roof and the driver trapped inside.
Crews managed to extricate the woman, who they say was conscious and alert.
She suffered numerous injuries and was taken to Frankford Hospital. No word on her condition.
There is also no word on what led to the accident. The investigation is ongoing.