It happened just after 3:00 a.m. Wednesday at the Grand Plaza Pharmacy on Bristol Pike.
Surveillance video shows the suspects breaking through the front door then rifling through drawers and shelves.
Police say they made off with two small trash cans full of narcotics.
If you have any information that can help police catch the burglars, you are asked to call Bensalem detectives at 215-633-3719.