Officers were called to the Burberry Store at 1705 Walnut Street around 11:20 a.m.
When police arrived employees told them two women came in and distracted them.
Then, four men ran into the store and stole the handbags, believed to be worth more than $16,000.
All six suspects then ran out of the store and jumped into a silver Ford Contour and fled the scene.
Anyone with information can call Philadelphia Police at 215-686-TIPS (8477)