Jeremy Renner's action tale "The Bourne Legacy" took over as the No. 1 movie with a $40.3 million debut, according to studio estimates Sunday.
Will Ferrell and Zach Galifianakis' political comedy "The Campaign" opened at No. 2 with $27.4 million.
The new movies pushed "The Dark Knight Rises" down to third-place with $19.5 million, raising the superhero blockbuster's three-week domestic total to $390.1 million.
The weekend's other new wide release, Meryl Streep and Tommy Lee Jones' marital comic drama "Hope Springs," opened at No. 4 with $15.6 million.
"The Dark Knight Rises" had been the No. 1 movie for three-straight weekends since debuting amid tragedy as a gunman killed 12 people and wounded 58 at a midnight screening of the film on opening day in Colorado.
The violence seems to have had little effect on the runaway success of the Batman finale.
"The opening weekend in our business is very important, and this incident took place before the picture officially opened. It took place at a midnight screening. I can't give you an actual number, but I'm sure we were affected on that opening," said Dan Fellman, head of distribution for Warner Bros., which released "The Dark Knight Rises."
Universal's "The Bourne Legacy" casts Renner and Rachel Weisz in an offshoot of the three hits that starred Matt Damon as unstoppable operative Jason Bourne. Renner plays an agent pursued by Bourne's old spy masters after they try to snuff out the espionage program in a cover-up conspiracy.
"The Bourne Legacy" came in well behind the $69.3 million debut of Damon's last entry in the series, 2007's "The Bourne Ultimatum." But the new film had a strong start and establishes Renner as a sturdy frontman to keep the franchise running.
"I love the fact that we were able to reboot this and do as well as we were able to. It leaves it open for us to think about it going forward," said Nikki Rocco, Universal's head of distribution. "We are very much into what it's going to look like the next time."
While Damon was absent, his presence is felt throughout "The Bourne Legacy," with characters commenting on Jason Bourne sightings and his former handlers jittery over the fact that the rogue agent is still out there.
Renner is a bankable star to carry on solo, but Universal might really cash in if the studio managed to lure Damon back.
"The dream-team scenario of a 'Bourne' with both Damon and Renner would just be irresistible," said Paul Dergarabedian, box-office analyst for Hollywood.com. "That would be cool. I'd be first in line for that."
"The Campaign" stars Ferrell and Galifianakis as rivals in a mud-slinging congressional election. Distributor Warner Bros. hopes real-life politics can help keep the movie afloat as the election season enters the homestretch.
"We hope so," Warner distribution boss Fellman said. "We hope they run their campaigns a little more professionally than the one in the movie, but sometimes, you have to wonder."
Sony's "Hope Springs," featuring Streep and Jones as a couple in marriage therapy at a weeklong retreat, had a modest start but drew strongly among older women, a crowd that does not tend to rush out in big numbers over opening weekend.
Rory Bruer, Sony's head of distribution, said the studio hopes the film will have a long shelf life at theaters as women talk it up to friends.
"The Dark Knight Rises" is nearing $400 million domestically and will become only the second film in Warner Bros. history to reach that mark. The first was 2008's "The Dark Knight," the middle chapter in director Christopher Nolan's Batman trilogy, which topped out at $533.3 million.
Revenues for the finale are running 12 percent behind "The Dark Knight," which had climbed to $441.6 million at the same point in its theatrical run.
While the Colorado shootings may have scared away some viewers, the Olympics have dampened Hollywood's overall business as fans stay home to watch the games. "The Dark Knight" also had an advantage the new film lacks: a mesmerizing, Academy Award-winning performance by Heath Ledger as the Joker, with the actor's death helping to fuel anticipation for the film.
"All things considered, 'The Dark Knight Rises' is doing incredibly well," Dergarabedian said.
"The Dark Knight Rises" has proven more popular than its predecessor overseas, where it has taken in $445.3 million to give it a worldwide total of $835 million. The finale is on track to top the $468 million international total of "The Dark Knight."
Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are also included. Final domestic figures will be released Monday.
1. "The Bourne Legacy," $40.3 million ($7.8 million international).
2. "The Campaign," $27.4 million ($2.1 million international).
3. "The Dark Knight Rises," $19.5 million ($34.2 million international).
4. "Hope Springs," $15.6 million.
5. "Diary of a Wimpy Kid: Dog Days," $8.2 million ($1 million international).
6. "Total Recall," $8.1 million ($18.7 million international).
7. "Ice Age: Continental Drift," $6.8 million ($16.2 million international).
8. "Ted," $3.3 million ($20.3 million international).
9. "Step Up: Revolution," $2.9 million.
10. "The Amazing Spider-Man," $2.2 million ($3 million international).
Estimated weekend ticket sales at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:
1. "The Dark Knight Rises," $34.2 million.
2. "Ted," $20.3 million.
3. "Total Recall," $18.7 million.
4. "Brave," $17.2 million.
5. "Ice Age: Continental Drift," $16.2 million.
6. "Madagascar 3: Europe's Most Wanted," $10.1 million.
7. "Step Up" Revolution," $9.9 million.
8. "The Thieves," $9 million.
9 (tie). "The Bourne Legacy," $7.8 million.
9 (tie). "Prometheus," $7.8 million.
Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.