It happened just before 6:00 p.m. in the 1200 block of West Rockland Street.
Police say a 20-year-old man and a 17-year-old man were taken to Albert Einstein Medical Center.
The 20-year-old was pronounced dead a short time later.
The 17-year-old was shot in the arm and is expected to survive.
Police are looking for a green Toyota Camry that fled the scene.