It happened shortly after midnight on the 200 block of Bank Street.
Firefighters quickly arrived on the scene after receiving several reports of flames coming from a home on the street.
Arriving crews were met with intense fire coming from the basement and went to work battling the blaze.
Firefighters also found a female victim suffering from smoke inhalation. She was taken to Capital Health Systems in an unknown condition.
The fire was brought under control but a cause is still under investigation.