The incident happened on July 7th around 4:15 a.m. at the store located in the 4200 block of North Broad Street.
The suspect was captured on surveillance video entering the Domino Pizza by using a key to open the front door, police say.
After the suspect entered the store he allegedly took an undetermined amount of cash from a safe.
After taking the cash the suspect locked the front doors and fled the location in an unknown direction.
The suspect is described as a black or Hispanic male, medium complexion and medium build.
He was wearing a black and blue Domino's Pizza cap, blue Domino Pizza's shirt, and navy blue pants.
He may have also been wearing a fake beard and sunglasses.
*To view the surveillance video: Visit the Philadelphia Police YouTube Channel or visit Philadelphia Police.
Anyone with information is asked to contact Philadelphia Police at 215-686-TIPS (8477), text a tip to PPD TIP (773847) or through PhillyPolice.com.